Publications

  1. E. Saxon, X. Peng, Recent Advances in Hydrogen Peroxide Responsive Organoborons for Biological and Biomedical Applications, ChemBioChem 2022, 23, e202100366.
  2. Heli Fan†, Muhammad Asad Uz Zaman†, Wenbing Chen†, Taufeeque Ali, Anahit Campbell, Qi Zhang, Nurul Islam Setu, Eron Saxon, Nicolas M. Zahn, Anna M. Benko, Leggy A. Arnold, and Xiaohua Peng. Assessment of Phenylboronic Acid Nitrogen Mustards as Potent and Selective Drug Candidates for Triple-Negative Breast Cancer, ACS Pharmacology & Translational Science 2021 4 (2), 687-702.
  3. H. Fan, H. Sun, Q. Zhang, X. Peng, Photoinduced DNA Interstrand Cross‐linking by 1,1’‐Biphenyl Analogues: Substituents and Leaving Groups Combine to Determine the Efficiency of Cross‐Linker, Chem. Eur. J. 2021, 27, 5215.
  4. Fan H, Peng X. Photoinduced DNA Interstrand Cross-Linking by Benzene Derivatives: Leaving Groups Determine the Efficiency of the Cross-Linker. J Org Chem. 2021 Jan 1;86(1):493-506.
  5. H. Fan, H. Sun, M. M. Haque, X. Peng. Effect of Triazole-Modified Thymidines on DNA and RNA Duplex Stability. ACS Omega 2019, 4, 5107−5116.
  6. W. Chen, H. Fan, K. Balakrishnan, Y. Wang, H. Sun, Y. Fan, V. Gandhi, L. A. Arnold, X. Peng. Discovery and Optimization of Novel Hydrogen Peroxide Activated Aromatic Nitrogen Mustard Derivatives as Highly Potent Anticancer Agents. J. Med. Chem. 2018, 61, 9132−9145.
  7. Z. Lin, H. Fan, Q. Zhang, X. Peng. Design, Synthesis, and Biological Investigation of New Binaphthalene Precursors as Efficient Photo-Activated DNA Interstrand Cross-Linkers. J. Org. Chem. 2018, 83, 8815−8826.
  8. H. Fan, H. Sun, X. Peng. Substituents Have a Large Effect on Photochemical Generation of Benzyl Cations and DNA Cross-Linking. Chem. Eur. J. 2018, 24, 7671 – 7682.
  9. Y. Wang, H. Fan, K. Balakrishnan, Z. Lin, S. Cao, W. Chen, Y. Fan, Q. A. Guthrie, H. Sun, K. A. Teske, V. Gandhi, L. A. Arnold, X. Peng. Hydrogen Peroxide Activated Quinone Methide Precursors with Enhanced DNA Cross-Linking Capability and Cytotoxicity towards Cancer Cells. Eur J Med Chem. 2017, 133, 197-207.
  10. H. Sun, H. Fan, H. Eom, X. Peng. Coumarin-Induced DNA Ligation, Rearrangement to DNA Interstrand Cross-Links, and Photo-Release of Coumarin Moiety. ChemBioChem. 2016, 17, 2046–2053.
  11. Y. Wang, Z. Lin, H. Fan, X. Peng. Photo-Induced DNA Interstrand Cross-Link Formation by Naphthalene Boronates via a Carbocation. Chem. Eur. J. 2016, 22, 10382–10386.
  12. Y. Wang, S. Liu, Z. Lin, Y. Fan, Y. Wang, X. Peng. Photochemical Generation of Benzyl Cations that Selectively Cross-Link Guanine and Cytosine in DNA. Org. Lett. 2016, 18, 2544–2547.
  13. Y. Han, W. Chen, Y. Kuang, H. Sun, Z. Wang, X. Peng. UV-Induced DNA Interstrand Cross-linking and Direct Strand Breaks from a New Type of Binitroimidazole Analogues. Chem. Res. Toxicol. 2015, 28, 915-926.
  14. H. Sun, H. Fan, X. Peng.* Quantitative DNA Interstrand Cross-link Formation by Coumarin and Thymine: Structure Determination, Sequence Effect, and Fluorescence Detection. J. Org. Chem. 2014, 79, 11359-11369.
  15. W. Chen, Y. Han, X. Peng. Aromatic Nitrogen Mustard-Based Prodrugs: Activity, Selectivity, and the Mechanism of DNA Cross-linking. Chem. Eur. J. 2014, 20, 7410-7418.
  16. W. Chen, K. Balakrishman, Y. Kuang, Y. Han, M. Fu, V. Gandhi, X. Peng. Reactive Oxygen Species (ROS) Inducible DNA Cross-Linking Agents and Their Effect on Cancer Cells and Normal Lymphocytes. J. Med. Chem. 2014, 57, 4498-4510.
  17. M. M. Haque, H. Sun, S. Liu, Y. Wang, X. Peng. Photo-Switchable DNA Interstrand Cross-Link Formation by a Coumarin-Modified Nucleotide. Angew. Chem. Int. Ed. 2014, 53, 7001-7005.
  18. S. Cao, Y. Wang, X. Peng. The Leaving Group Strongly Affects H2O2‑Induced DNA Cross-Linking by Arylboronates. J. Org. Chem. 2014, 79, 501-508.
  19. S. Cao, X. Peng. Exploiting Endogenous Cellular Process to Generate Quinone Methides in vivo. Curr. Org. Chem. 2014, 18, 70-85.
  20. M. M. Haque, X. Peng. DNA Associated Click Chemistry. Sci. China Chem. 2014, 57 (2), 215-231.
  21. H. Sun, X. Peng. Template-Directed Fluorogenic Oligonucleotide Ligation Using “Click” Chemistry: Detection of Single Nucleotide Polymorphism in the Human p53 Tumor Suppressor Gene. Bioconjugate Chem. 2013, 24, 1226−1234.
  22. S. Cao, R. Christiansen, X. Peng. Substituent Effects on Oxidation‐Induced Formation of Quinone Methides from Arylboronic Ester Precursors. Chem. Eur. J. 2013, 19, 9050-9058.
  23. Y. Kuang, H. Sun, J. C. Blain, X. Peng. Hypoxia-Selective DNA Interstrand Cross-Link Formation by Two Modified Nucleosides. Chem. Eur. J. 2012, 18, 12609-12613.
  24. X. Peng, V. Gandhi. ROS-Activated Anticancer Prodrugs: A New Strategy for Tumor-Specific Damage. Therapeutic Delivery 3 2012, 7, 823-833.
  25. C. Sheng, Y. Wang, X. Peng. ROS-Inducible DNA Cross-linking Agent as a New Anticancer Prodrug Building Block. Chem. Eur. J. 2012, 18, 3850-3854.
  26. Y. Kuang, Balakrishnan, K.; Gandhi, V.; X. Peng. Hydrogen Peroxide Inducible DNA Cross-Linking Agents: Targeted Anticancer Prodrugs. J. Am. Chem. Soc. 2011, 133, 19278-19231.

Book Chapter

  1. H. Fan, X. Peng. “Novel DNA Cross-Linking Agents and Their Applications” in “Advances in Molecular Toxicology Volume 10”, Ed. J. Fishbein, Elsevier, 2016, 10, 235-292.